The effect of chronic administration of nicotine on antinociception, opioid receptor binding and met-enkelphalin levels in rats
β Scribed by Mary Ellen Wewers; Ravinder K Dhatt; Therese A Snively; Gopi A Tejwani
- Book ID
- 114004703
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 111 KB
- Volume
- 822
- Category
- Article
- ISSN
- 0006-8993
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Nicotine (0.16--0.50 mg/kg, SC) was found to exert a potent antinociceptive action on thermal stimuli as measured by the tail-flick test. This antinociceptive action of nicotine could be blocked by centrally active nicotinic or muscarinic blockers implicating both classes of cholinergic receptors in
The effect of acute and chronic nicotine treatment of rats on the mRNA levels coding for the three opioid peptide precursors, for provasopressin and for the c~3 subunit of nicotinic receptors in brain, pituitary and/or adrenal medulla of rats was investigated. Nicotine was found to increase the leve