The effect of cholesterol on the viscosity of protein-lipid monolayers

✍ Scribed by Martin Blank; Lily Soo

• Publisher: Elsevier Science
• Year: 1976
• Tongue: English
• Weight: 489 KB
• Volume: 17
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(76)90043-8

✦ Synopsis

The addition of cholesterol to • layer of ltpids in • membrl~ stngtuge is ~ believed to result in an increase in the vlgodty ot the bye:. We have shown that cholesterol and two other monolayer-fotminl llpklt mm4cedly d~ the ~ of • mrum almmln mtmolaym at the ane-water interface, • model membrane system. Hcmuvu, when the pmtela mono-lay~ already has a nnfaae active llpld component preset, the effect et added dtolmteml depends upoe the other mbstance, When the almmtn monobyet coutalm trlstearin, added cholm, terol im:teaae, the vtacoslty. When the lipid is oetadecaaol, ~I decremn the v'bcodty. The dependence of the change in Imeff~hd vhcodty due to ¢holmnml upon the orlgtmd compogttlon of the interf~-btl h,yer may be uleful for ~ the compolttton of laym of unknown compodtlon, e.g. some natural membranes.