The Effect of Carbapenem Antibiotics on Plasma Concentrations of Valproic Acid
โ Scribed by Mancl, E. E; Gidal, B. E
- Book ID
- 126216875
- Publisher
- Harvey Whitney Books Company
- Year
- 2009
- Tongue
- English
- Weight
- 166 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1060-0280
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๐ SIMILAR VOLUMES
Serial plasma samples collected after an acute administration of valproic acid, (VPA, 15 mg/kg as oral solution) in epileptic patients were selected for this study. The plasma samples were selected from three different groups of patients; patients on phenobarbital and phenytoin with clinical VPA int
Carbapenem antibiotics cause pharmacokinetic interaction with valproic acid (VPA) in clinical pharmacotherapy. Here, we investigated the mechanism of interaction from the viewpoint of erythrocyte distribution of VPA in rats and humans. Imipenem or panipenem was administered intravenously and then VP