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Inhibition by carbapenem antibiotic imipenem of intestinal absorption of valproic acid in rats

✍ Scribed by Mayumi Torii; Yoshiharu Takiguchi; Fumiko Saito; Miyako Izumi; Masayuki Yokota

Book ID
111768704
Publisher
Pharmaceutical Press
Year
2001
Tongue
English
Weight
147 KB
Volume
53
Category
Article
ISSN
2042-7158

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πŸ“œ SIMILAR VOLUMES

Increased erythrocyte distribution of va
Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human
✍ Kei Omoda; Teruo Murakami; Ryoko Yumoto; Junya Nagai; Yorinobu Maeda; Yoshie Kir πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 125 KB

Carbapenem antibiotics cause pharmacokinetic interaction with valproic acid (VPA) in clinical pharmacotherapy. Here, we investigated the mechanism of interaction from the viewpoint of erythrocyte distribution of VPA in rats and humans. Imipenem or panipenem was administered intravenously and then VP