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The effect of caffeine on the pharmacokinetics of acetaminophen in man

โœ Scribed by Nadeem Iqbal; Bashir Ahmad; Khalid Hussain Janbaz; Anwar-Ul Hassan Gilani; Sarfaraz Khan Niazi

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
399 KB
Volume
16
Category
Article
ISSN
0142-2782

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โœฆ Synopsis

The influence of caffeine (60 mg) was studied on the pharmacokinetic characteristics of acetaminophen (500 mg single dose) in ten healthy male human volunteers in a complete cross-over design. A high-performance liquid chromatography (HPLC) method was used to analyse serum drug concentrations. Caffeine caused a highly significant (p < 0.01) increase in AUC and AUMC, a significant (p < 0.05) increase in C-, and a significant (p < 0.05) decrease in clearance (Cl/F) of acetaminophen. We conclude that caffeine taken in doses commonly available commercially or in a cup of coffee can significantly potentiate the therapeutic potential of acetaminophen in man.

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