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The effect of an oral therapeutic single-dose of griseofulvin on polymorphonuclear leukocyte migration in a casein gradient

✍ Scribed by U. Bandmann; O. Bäck; B. Norberg

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
338 KB
Volume
276
Category
Article
ISSN
0340-3696

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✦ Synopsis

In a previous study, polymorphonuclear (PMN) leukocyte chemotaxis in vitro was inhibited by therapeutic concentrations of griseofulvin. In the present investigation, P M N migration in a casein gradient was studied in a cell suspension containing serum collected before and after a therapeutic peroral singledose of griseofulvin. The P M N migration in vitro was not influenced significantly by the presence of griseofulvin-containing serum. It is suggested that peroral griseofulvin treatment has neglibible effect on P M N chemotaxis in vitro.

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