𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of a single oral dose of pp′DDT on the absorption of nutrients in vitro and on brush border enzymes in rat intestine

✍ Scribed by Pradeep K. Dudeja; Akhtar Mahmood

Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
446 KB
Volume
49
Category
Article
ISSN
0340-5761

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of a single oral dose of pp'DDT (100 mg/kg body wt.) has been studied on the intestinal uptake of certain nutrients and on brush border enzymes in rats. Intestinal uptake of leucine, and phenylalanine was considerably increased but there was no change in the absorption of glucose and alanine in DDT fed rats, compared to controls. The activities of brush border sucrase, alkaline phosphatase and Na+, K+-ATPase were significantly depressed in pesticide treated animals, but leucine aminopeptidase levels remained unaffected under these conditions. Analysis of the chemical composition of the microvillus membranes revealed a considerable enhancement in total lipids, phospholipids and triglyceride contents of the membranes in DDT exposed rats, but membrane protein, sialic acid and cholesterol fractions did not record any change. 1-14C-acetate incorporation into various lipid classes was studied to explain the observed increase in membrane lipids in DDT exposed animals.

📜 SIMILAR VOLUMES

The effect of oral dose volume on the ab
The effect of oral dose volume on the absorption of a highly and a poorly water soluble drug in the rat
✍ David F. Nickerson; Margaret L. Weaver; Francis L. S. Tse 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 488 KB 👁 3 views

## Abstract The influence of dose volume on drug absorption following oral administration of a highly and a poorly water soluble drug was examined in male Sprague‐Dawley rats. A constant mass of each ^14^C‐labeled compound was given via gavage in dose volumes of 1, 5, 10, and 20 mL kg^−1^. Blood le

Studies of the in vitro effect of methyl
Studies of the in vitro effect of methylmercury chloride on rat brain neurotransmitter enzymes
✍ Mei-Ping Kung; Paul Kostyniak; James Olson; Maureen Malone; Jerome A. Roth 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 293 KB 👁 1 views

The in vitro effect of methylmercury (MM) on the enzymatic activities of brain cell specific marker enzymes, choline acetyltransferase (CAT), glutamic acid decarboxylase (GAD), 2', 3'-cyclic nucleotide phosphohydrolase (CNP), glutamine synthetase (GS) and enolase was examined. The results demonstrat

Effects of citronellal, a monoterpenoid
Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo
✍ Naoko Yoshida; Akiyoshi Takagi; Hidenori Kitazawa; Junichi Kawakami; Isao Adachi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 155 KB

Complementary and alternative medicines can be applied concomitantly with conventional medicines; however, little drug information is available on these interactions. Previously, we reported on the inhibitory effects of an extract and monoterpenoids (e.g., (R)-(þ)-citronellal) contained in citrus he

A study of the effects of clonidine on t
A study of the effects of clonidine on the EEG in rats treated with single and multiple doses of antidepressants
✍ Wojciech Kostowski; Wanda Dyr; Bodgan Zacharski 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 640 KB

The influence of repeated and single administrations of desipramine, amitryptiline, and mianserin on the EEG effects of clonidine has been investigated in rats implanted with chronic cortical electrodes. Clonidine induced a dose-dependent EEG synchronization in control animals. Signs of behavioral d