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The effect of allopurinol on the steady-state pharmacokinetics of indomethacin.

✍ Scribed by T. Pullar; O. Myall; J.R. Haigh; J.R. Lowe; JS Dixon; HA Bird

Book ID: 117944614
Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 341 KB
Volume: 25
Category: Article
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1988.tb05263.x

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## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^−1^) during a continuous MTX infusion (1·2 mg kg^−1^) over 240 min. IND was injected i.v. at hourly intervals after a steady