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The effect of aging on the DNA damage and repair capacity in 2BS cells undergoing oxidative stress

✍ Scribed by Jin-Ling Wang; Pei-Chang Wang

Publisher: Springer
Year: 2011
Tongue: English
Weight: 527 KB
Volume: 39
Category: Article
ISSN: 0301-4851
DOI: 10.1007/s11033-011-0731-4

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## Abstract Repair of some oxidized purines such as 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) is inefficient in human cells in comparison to repair of other major endogenous lesions (__e.g.__ uracil, abasic sites or oxidized pyrimidines). This is due to the poor catalytic properties of hOGG1, the major DNA