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The effect of age and temperature on MDX muscle fatigue

✍ Scribed by Mark A. Wineinger; Sandra A. Walsh; Richard T. Abresch

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 96 KB
Volume: 21
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199808)21:8<1075::aid-mus14>3.0.co;2-t

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✦ Synopsis

We have studied the in vitro contractile and fatigue characteristics of extensor digitorum longus (EDL) muscles from 8- and 62-week-old dystrophin-deficient (mdx) and control mice at 20 degrees C and 35 degrees C. There were no differences in fatigability at 20 degrees C, but at 35 degrees C the dystrophin-deficient muscles demonstrated increased fatigability compared to controls, with the older mice exhibiting the greatest fatigue. These results suggest a temperature-related mechanism of myofibrillar fatigue in dystrophin-deficient EDL muscles.

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