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The effect of age and postsplenectomy interval on the susceptibility of the asplenic adult rat to pneumococcal challenge

โœ Scribed by Jane F. Goldthorn; Allen D. Schwartz

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
300 KB
Volume
11
Category
Article
ISSN
0022-4790

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โœฆ Synopsis

The response t o intravenous challenge with pneumococcus was examined in asplenic and sham-operated adult Sprague-Dawley rats eighteen weeks following surgery. The LD50 was over 2,000-fold greater in the sham-operated animals than in the asplenic animals. These results suggest that the age of an asplenic host, the length of time following splenectomy, and the presence of a normal immune system other than the asplenic state do not in themselves confer immunity.

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