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The effect of 5α-reductase-2 deficiency on human fertility

✍ Scribed by Kang, Hey-Joo; Imperato-McGinley, Julianne; Zhu, Yuan-Shan; Rosenwaks, Zev


Book ID
122262786
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
638 KB
Volume
101
Category
Article
ISSN
1556-5653

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Conversion of testosterone (T) to dihydrotestosterone (DHT) in genital tissue is catalysed by the enzyme 5a-reductase 2, which is encoded by the SRD5A2 gene. The potent androgen DHT is required for full masculinization of the external genitalia. Mutations of the SRD5A2 gene inhibit enzyme activity,