𝔖 Bobbio Scriptorium
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Androgens and male physiology the syndrome of 5α-reductase-2 deficiency

✍ Scribed by J Imperato-McGinley; Y.-S Zhu


Book ID
117463245
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
302 KB
Volume
198
Category
Article
ISSN
0303-7207

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Conversion of testosterone (T) to dihydrotestosterone (DHT) in genital tissue is catalysed by the enzyme 5a-reductase 2, which is encoded by the SRD5A2 gene. The potent androgen DHT is required for full masculinization of the external genitalia. Mutations of the SRD5A2 gene inhibit enzyme activity,