The effect of 3-aminobenzamide on X-ray induction of chromosome aberrations in Down syndrome lymphocytes
β Scribed by Renate A. MacLaren; William W. Au; Marvin S. Legator
- Book ID
- 119093241
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 473 KB
- Volume
- 222
- Category
- Article
- ISSN
- 0165-1218
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π SIMILAR VOLUMES
Down syndrome (DS) individuals are known to be predisposed to develop leukemia and their lymphocytes are highly sensitive to the induction of chromosome aberrations by X-rays. A study was conducted to identify the chromosome breakpoints and to evaluate whether site specificity for chromosome breakag
## Abstract Unstimulated lymphocytes from individuals with Down Syndrome (trisomy 21) are more sensitive to the induction of dicentric and ring aberrations by X rays than normal lymphocytes. Several explanations involving the more rapid rejoining of Xβrayβinduced lesions in Down cells have been off