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X-ray-induced chromosome aberrations in down lymphocytes: An explanation of their increased sensitivity

✍ Scribed by Preston, R. Julian

Publisher: Wiley (John Wiley & Sons)
Year: 1981
Weight: 317 KB
Volume: 3
Category: Article
ISSN: 0192-2521
DOI: 10.1002/em.2860030109

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✦ Synopsis

Abstract

Unstimulated lymphocytes from individuals with Down Syndrome (trisomy 21) are more sensitive to the induction of dicentric and ring aberrations by X rays than normal lymphocytes. Several explanations involving the more rapid rejoining of X‐ray–induced lesions in Down cells have been offered. It is shown here that the repair of the DNA damage converted into chromosome aberrations is more rapid in Down cells than normal cells. This more rapid repair results in a higher probability of producing chromosome aberrations, and hence higher aberration frequencies in Down than normal cells.

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