The E-Cadherin ( CDH1 ) −C160A Polymorphism and Colorectal Cancer Susceptibility: A Meta-Analysis
✍ Scribed by Geng, Peiliang; Chen, Yuying; Ou, Juanjuan; Yin, Xiaoling; Sa, Rina; Liang, Houjie
- Book ID
- 118062557
- Publisher
- Mary Ann Liebert
- Year
- 2012
- Tongue
- English
- Weight
- 633 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1044-5498
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## Abstract Part of the inherited susceptibility to colorectal cancer (CRC) is caused by the coinheritance of common low risk variants. E‐cadherin (__CDH1__) has an established role in CRC; somatic inactivation of __CDH1__ is a common early event, and germline mutations can cause early‐onset CRC. T
## Abstract Cyclin D1 (CCND1) and E‐cadherin (CDH1) have been shown to be important genes of the β‐catenin/LEF pathway that is involved in colorectal carcinogenesis. However, epidemiological studies on relationship between genetic variants of these two genes and colorectal cancer (CRC) have shown i