The E-cadherin (CDH1) −160 C/A polymorphism and prostate cancer risk: a meta-analysis
✍ Scribed by Qiu, Li-Xin; Li, Ru-Tian; Zhang, Jian-Bing; Zhong, Wen-Zhao; Bai, Jian-Ling; Liu, Bao-Rui; Zheng, Ming-Hua; Qian, Xiao-Ping
- Book ID
- 109847782
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 112 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1018-4813
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## Abstract Part of the inherited susceptibility to colorectal cancer (CRC) is caused by the coinheritance of common low risk variants. E‐cadherin (__CDH1__) has an established role in CRC; somatic inactivation of __CDH1__ is a common early event, and germline mutations can cause early‐onset CRC. T
## Abstract The __E‐cadherin__ (__CDH1__) gene has been associated with prostate carcinogenesis. The C/A polymorphism −160 base pairs relative to the transcription start site has been shown to decrease gene transcription. We analyzed the association between this polymorphism and the risk of sporadi