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The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma

✍ Scribed by Bhende, P M; Park, S I; Lim, M S; Dittmer, D P; Damania, B


Book ID
109887195
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
428 KB
Volume
24
Category
Article
ISSN
0887-6924

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The efficacy of a novel, dual PI3K/mTOR
✍ Niranjan Awasthi; Peter L. Yen; Margaret A. Schwarz; Roderich E. Schwarz πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons 🌐 English βš– 419 KB

## Abstract Gemcitabine has limited clinical benefits for pancreatic ductal adenocarcinoma (PDAC). The phosphatidylinositol‐3‐kinase (PI3K)/AKT and mammalian target of rapamycin (mTOR) signaling pathways are frequently dysregulated in PDAC. We investigated the effects of NVP‐BEZ235, a novel dual PI