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The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model for Sporadic Colorectal Cancer

✍ Scribed by Jatin Roper; Michael P. Richardson; Wei Vivian Wang; Larissa Georgeon Richard; Wei Y. Chen; Erin M. Coffee; Lydia Lee; Peng-Chieh Chen; Roderick T. Bronson; Eric S. Martin; Kenneth E. Hung


Book ID
119432272
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
198 KB
Volume
140
Category
Article
ISSN
0016-5085

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The efficacy of a novel, dual PI3K/mTOR
✍ Niranjan Awasthi; Peter L. Yen; Margaret A. Schwarz; Roderich E. Schwarz 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB

## Abstract Gemcitabine has limited clinical benefits for pancreatic ductal adenocarcinoma (PDAC). The phosphatidylinositol‐3‐kinase (PI3K)/AKT and mammalian target of rapamycin (mTOR) signaling pathways are frequently dysregulated in PDAC. We investigated the effects of NVP‐BEZ235, a novel dual PI