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808: The PI3K/mTOR inhibitor NVP-BEZ235 is able to revert selumetinib resistance in colorectal cancer cellular models

✍ Scribed by Martinez-Lacaci, I.; Carballo-Santana, M.; Tristante, E.; Mayor-López, L.; Grasso, S.; Carbonell, P.; De Torre, C.; Luján, J.; Alonso, J.L.; Carballo, F.


Book ID
125796766
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
64 KB
Volume
50
Category
Article
ISSN
0959-8049

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The efficacy of a novel, dual PI3K/mTOR
✍ Niranjan Awasthi; Peter L. Yen; Margaret A. Schwarz; Roderich E. Schwarz 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB

## Abstract Gemcitabine has limited clinical benefits for pancreatic ductal adenocarcinoma (PDAC). The phosphatidylinositol‐3‐kinase (PI3K)/AKT and mammalian target of rapamycin (mTOR) signaling pathways are frequently dysregulated in PDAC. We investigated the effects of NVP‐BEZ235, a novel dual PI