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The down-regulated expression of 14-3-3σ may activate the other six 14-3-3 isoforms and they may take over the role of 14-3-3σ in the tumor genesis

✍ Scribed by Xiaoliang Yang; Jie Zhou; Weidong Cao; Xiang Zhang; Zhou Fei


Book ID
119195714
Publisher
Elsevier
Year
2009
Tongue
English
Weight
127 KB
Volume
2
Category
Article
ISSN
1756-2392

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Hypomethylation of the 14-3-3σ promoter
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## Abstract The 14‐3‐3 proteins are a set of seven highly conserved proteins that have recently been implicated in having a role in human tumorigenesis. However, the mechanism by which 14‐3‐3 proteins may act in this capacity is not well understood. In this study, we examined the expression of one