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The dopamine D2 agonist LY 141865, but not the D1 agonist SKF 38393, reverses parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset

✍ Scribed by Nomoto, M.; Jenner, P.; Marsden, C.D.


Book ID
123208621
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
273 KB
Volume
57
Category
Article
ISSN
0304-3940

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## Abstract At present, the pharmacotherapy of Parkinson's disease (PD) consists mainly of L‐dihydroxyphenylalanine (L‐DOPA) and/or dopamine D~2~ receptor agonist. However, in general the clinical efficacy of D~2~ agonists is less than that of L‐DOPA. Therefore, attention is being focussed on the r