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The dominant-negative effect of p53 mutants and p21 induction in tetraploid G1 arrest depends on the type of p53 mutation and the nature of the stimulus

✍ Scribed by Walid Dridi; Raouf Fetni; Josée Lavoie; Marie-France Poupon; Régen Drouin

Book ID
114135536
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
365 KB
Volume
143
Category
Article
ISSN
0165-4608

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## Abstract In addition to the loss of function, mutant p53 can possess a dominant‐negative effect on wild‐type p53 and may also exert gain‐of‐function activity. It is not clear whether the functional status of __p53__ mutation contributes to differences in outcome in endometrial cancer. We collect