The yeast Saccharomyces cerevisiae is mortal. Before they die, individual yeasts bud repeatedly producing a finite number of progeny, which have the capacity for a full life span. A feature of aging in many species is the waning of resistance to stress. To determine whether this is the case in yeast
The DNA damage response during DNA replication
β Scribed by Dana Branzei; Marco Foiani
- Book ID
- 113524727
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 339 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0955-0674
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The initiation protein DnaA of Escherichia coli regulates its own expression autogenously by binding to a 9 bp consensus sequence, the dnaA box, between the promoters dnaAP1 and dnaAP2. In this study, we analysed dnaA regulation in relation to DNA damage and found dnaA expression to be inducible by
## Abstract Human replication protein A (RPA), a heterotrimeric protein complex, was originally defined as a eukaryotic singleβstranded DNA binding (SSB) protein essential for the in vitro replication of simian virus 40 (SV40) DNA. Since then RPA has been found to be an indispensable player in almo