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DNA lesions that block DNA replication are responsible for the dnaA induction caused by DNA damage

✍ Scribed by Quiñones, Ariel ;Jueterbock, Wolf-Rainer ;Messer, Walter

Book ID: 104708735
Publisher: Springer
Year: 1991
Tongue: English
Weight: 853 KB
Volume: 231
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00293825

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✦ Synopsis

The initiation protein DnaA of Escherichia coli regulates its own expression autogenously by binding to a 9 bp consensus sequence, the dnaA box, between the promoters dnaAP1 and dnaAP2. In this study, we analysed dnaA regulation in relation to DNA damage and found dnaA expression to be inducible by DNA lesions that inhibit DNA replication. On the other hand, coding DNA lesions were not able to induce dnaA expression. These results suggest that an additional regulatory mechanism is involved in dnaA gene expression and that DnaA protein may play a role in cellular responses to DNA damage. Furthermore, they strongly suggest that in response to DNA replication inhibition by DNA damage, and enhanced (re)initiation capacity is induced by oriC.

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