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The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

✍ Scribed by Melissa L. Fishel; Mark R. Kelley

Book ID: 116727933
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 261 KB
Volume: 28
Category: Article
ISSN: 0098-2997
DOI: 10.1016/j.mam.2007.04.005

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## Abstract ## BACKGROUND. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base‐excision repair (BER) pathway, in which adenosine diphosphate ribosyl transferase (ADPRT), x‐ray repair cross‐complementing 1 (XRCC1),