The Distribution of Cartilage Oligomeric Matrix Protein (COMP) in Equine Carpal Articular Cartilage and its Variation with Exercise and Cartilage Deterioration
β Scribed by R.C. MURRAY; R.K. SMITH; F.M.D. HENSON; A. GOODSHIP
- Book ID
- 114481879
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 83 KB
- Volume
- 162
- Category
- Article
- ISSN
- 1090-0233
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π SIMILAR VOLUMES
Pseudoachondroplasia (PSACH) is an autosomal dominant dwarfing condition characterized by disproportionate short stature, joint laxity, and early-onset osteoarthrosis. PSACH is caused by mutations in the gene encoding cartilage oligomeric matrix protein (COMP). We are reporting on mutations in COMP
Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti