The distribution of arsenic and cobalt in patients with laryngeal carcinoma

✍ Scribed by Paola Collecchi; Mauro Esposito; Silvio Brera; Enzo Mora; Ambrogio Mazzucotelli; Massimo Oddone

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 285 KB
• Volume: 6
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550060410

✦ Synopsis

The objective of this study was to evaluate tissue and plasma concentrations of arsenic and cobalt in an attempt to discover the role of these elements in the malignant process. Using neutron activation analysis, arsenic and cobalt levels were determined in plasma and in nonmalignant and malignant human tissues in 15 patients with laryngeal carcinoma. Arsenic and cobalt levels were about 60% higher in tumor than in adjacent non-malignant tissue (P< 0,001): arsenic 72.4 * 18.0 ng/g versus 43.1 f 9.4 in non-malignant tissues, and cobalt 68.7 f 7.3 ng/g versus 39.6 f 7.0 in nonmalignant tissues. Mean plasma arsenic and cobalt levels were also significantly higher in patients with laryngeal carcinoma than in healthy control subjects.