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The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen

✍ Scribed by Wolfgang Vogel; Gerald D Gish; Frauke Alves; Tony Pawson

Book ID
117736002
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
387 KB
Volume
1
Category
Article
ISSN
1097-2765

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## Abstract The discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is highly expressed in breast carcinoma cells. Upon binding to collagen, DDR1 undergoes autophosphorylation followed by limited proteolysis to generate a tyrosine phosphorylated C‐terminal fragment (CTF). Although