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Discoidin Domain Receptor (DDR) 1 and 2: Collagen-activated Tyrosine Kinase Receptors in the Cornea

✍ Scribed by Mohan, R. R. (author);Mohan, R. R. (author);Wilson, S. E. (author)

Book ID
115605661
Publisher
Academic Press
Year
2001
Tongue
English
Weight
220 KB
Volume
72
Category
Article
ISSN
0014-4835

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## Abstract The discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is highly expressed in breast carcinoma cells. Upon binding to collagen, DDR1 undergoes autophosphorylation followed by limited proteolysis to generate a tyrosine phosphorylated C‐terminal fragment (CTF). Although