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The direct synthesis of novel enantiomerically pure α-amino acids in protected form via Suzuki cross-coupling

✍ Scribed by Philip N Collier; Andrew D Campbell; Ian Patel; Richard J.K Taylor

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
215 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

Protected allylglycine has been hydroborated and the intermediate organoborane employed in Suzuki coupling reactions with a number of ole®nic, aromatic and heteroaromatic bromides and iodides to produce a range of novel a-amino acids in good, unoptimised yields.

📜 SIMILAR VOLUMES

The synthesis of novel amino acids via h
The synthesis of novel amino acids via hydroboration-Suzuki cross coupling
✍ Andrew D. Campbell; Tony M. Raynham; Richard J.K. Taylor 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 212 KB

The Garner aldehyde-derived methylene alkene has been hydroborated using 9-BBN and the resulting organoborane employed in palladiurn-catalysed Suzuki coupling reactions to produce, offer hydrolysis-oxidation, a range of novel amino acids as their N-BOC protected derivatives.