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The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures

✍ Scribed by Piotr Maciejak; Janusz Szyndler; Małgorzata Lehner; Danuta Turzyńska; Alicja Sobolewska; Andrzej Bidziński; Adam Płaźnik


Book ID
116980019
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
618 KB
Volume
18
Category
Article
ISSN
1525-5050

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The effect of inhibiting endogenous brain thromboxane (TXB2) on pentylenetetrazole-induced seizures was studied using the thromboxane synthetase inhibitors OKY-1581 (20 mgikg) and UK 38,485 (50 mgikg). Both compounds selectively decreased ( > 90%) TXB2 production in brain measured after 2 min of con