The effect of inhibiting brain thromboxane biosynthesis on pentylenetetrazole-induced seizure threshold
✍ Scribed by S. McGinley; M. Centra; T.W. Lysz
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 276 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0360-4012
No coin nor oath required. For personal study only.
✦ Synopsis
The effect of inhibiting endogenous brain thromboxane (TXB2) on pentylenetetrazole-induced seizures was studied using the thromboxane synthetase inhibitors OKY-1581 (20 mgikg) and UK 38,485 (50 mgikg). Both compounds selectively decreased ( > 90%) TXB2 production in brain measured after 2 min of convulsive activity but had no effect on brain PGE2, PGF2,, or 6-keto-PGFl,. No effect of these agents on the tonic seizure threshold was observed, whereas 10 mg/kg ip indomethacin, an agent which inhibits both TXB2 and prostaglandin production, reduced the tonic seizure threshold from 78 & 2.6 mg/kg in controls to 62 & 3.7 mg/kg. Thus, this study concludes that the availability of TXB2 with convulsant activity is unlikely to be a factor in altering tonic seizure activity observed with indomethacin.