The diastereoselective synthesis of (+)-actinobolin from D-glucose
โ Scribed by Dale E. Ward; Brian F. Kaller
- Book ID
- 103407509
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 272 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The preparation of (-)-16 from (+)-3 constitutes a formal enuntiospecific synthesis of (-)-bactobotin from D-glucose. The key traasfonnation involves the diustereoselective addition of LiCHCl2 to 7 in the presence of CeC13. The synthesis of (+)-3 from (+)-uctinobolin sulfate is reported and illustra
Summazy: The broad spectrum antibiotic (+)-negamycin (1) was prepared from 1,2-o-isopropylidene-D-glucose (3) in nine steps. Negamycin ( 1) is a broad spectrum antibiotic elaborated by ~iepfOr?ltjCeb puip~O~ubcub.l
OAc z f2E) 21 t4T3) '33, 2333 ; b) Legraverend,M.; Lhoste, J.M.; Bisagni,E. Tetrahedron la, 40, 709. 23) The magnitude of NOE (X) given in the parenthesis was observed when the underlined proton was irradiated.