The development of new biotechnologies using metalloprotein design

✍ Scribed by David E Benson; Michael S Wisz; Homme W Hellinga

• Book ID: 104362090
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 646 KB
• Volume: 9
• Category: Article
• ISSN: 0958-1669
• DOI: 10.1016/s0958-1669(98)80010-4

✦ Synopsis

A variety of methodologies are under development to alter the behavior of existing metal centers or create entirely new sites within a protein framework in order to exploit the intrinsic chemical versatility of metals using the. exquisite level of control that a protein matrix can exert to modulate their reactivity. Even at this relatively early stage, engineering of metal centers has led to the development of a number of emerging technologies with a wide variety of applications, including affinity purification of proteins, engineering of metalmediated protein stability, control of protein activity, imaging and therapy, biosensors, and new catalysts.