## Abstract Significant progress has been made in recent years toward creating interesting, unique, and in some cases, predictable oligopeptoid/polypeptoid secondary, tertiary, and in one case, quaternary structures. This article describes this progress, identifies a few of the many remaining chall
Designer Proteins: On the Art of Synthesizing De Novo Metalloproteins
β Scribed by Dr. Heinz-Bernhard Kraatz
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 207 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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## Abstract We investigated the hydrophobic packing of two previously designed caviteins, LG2 and LG3, which differ by one Gly in the linker regions between the peptide sequence and the cavitand scaffold. We sought to diminish the putative nativeβlike properties of LG2 and LG3, and see if we could
Reduced lattice models of the three de novo designed helical proteins β£ 2 , β£ 2 C, and β£ 2 D were studied. Low temperature stable folds were obtained for all three proteins. In all cases, the lowest energy folds were four-helix bundles. The folding pathway is qualitatively the same for all proteins
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