𝔖 Bobbio Scriptorium
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The development of difference turbidimetric analysis for monoclonal antibodies to human IgG

✍ Scribed by J Steensgaard; C Jacobsen; Jennifer Lowe; Debbie Hardie; NR Ling; R Jefferis


Book ID
119088684
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
413 KB
Volume
17
Category
Article
ISSN
0161-5890

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✍ Roxana M. Ionescu; Josef Vlasak; Colleen Price; Marc Kirchmeier πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 354 KB

Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental