✦ LIBER ✦

The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases

✍ Scribed by Shayman, J. A.; Larsen, S. D.

Book ID: 125830937
Publisher: Lipid Research, Inc.
Year: 2014
Tongue: English
Weight: 579 KB
Volume: 55
Category: Article
ISSN: 0022-2275
DOI: 10.1194/jlr.R047167

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Toward the discovery of small molecule P

Toward the discovery of small molecule PTP1B inhibitors for the treatment of metabolic diseases

✍ Andrew J. Nichols; Robert D. Mashal; Bork Balkan 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 2 views

## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for down‐regulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we

Novel orally available brain penetrant s

Novel orally available brain penetrant small molecule inhibitors of ganglioside biosynthesis for the treatment of Sandhoff and Tay–Sachs diseases

✍ Bai, Xiaomei; Sun, Hong; Tang, Lan; Duron, Sergio; Bhagwat, Shripad; Crawford, B 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 309 KB

561 POSTER Discovery and preclinical cha

561 POSTER Discovery and preclinical characterization of a series of novel JAK2 small molecule inhibitors for the treatment of myeloproliferative diseases

✍ K.A. Jessen; S. Leonard; K. Froning; C. Tang; C. Smith; D. Ellis; S. Sperry; S. 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 61 KB

Extended use of a selective inhibitor of

Extended use of a selective inhibitor of acid lipase for the diagnosis of Wolman disease and cholesteryl ester storage disease

✍ Civallero, G.; De Mari, J.; Bittar, C.; Burin, M.; Giugliani, R. 📂 Article 📅 2014 🏛 Elsevier Science 🌐 English ⚖ 250 KB

Small molecule PAI-1 functional inhibito

Small molecule PAI-1 functional inhibitor attenuates vascular smooth muscle cell migration and survival: Implications for the therapy of vascular disease

✍ Simone, Tessa M. ;Higgins, Paul J. 📂 Article 📅 2014 🏛 Ubiquity Press, Ltd. 🌐 English ⚖ 301 KB

Small-molecule inhibitors/modulators of

Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012)

✍ Belluti, Federica; Rampa, Angela; Gobbi, Silvia; Bisi, Alessandra 📂 Article 📅 2013 🏛 Informa plc 🌐 English ⚖ 716 KB