✦ LIBER ✦

561 POSTER Discovery and preclinical characterization of a series of novel JAK2 small molecule inhibitors for the treatment of myeloproliferative diseases

✍ Scribed by K.A. Jessen; S. Leonard; K. Froning; C. Tang; C. Smith; D. Ellis; S. Sperry; S. Gessert; S. Reich; S.G. Buchanan

Book ID: 119599717
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 61 KB
Volume: 6
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(08)72495-9

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Toward the discovery of small molecule P

Toward the discovery of small molecule PTP1B inhibitors for the treatment of metabolic diseases

✍ Andrew J. Nichols; Robert D. Mashal; Bork Balkan 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 2 views

## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for down‐regulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we

Discovery and functional characterizatio

Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2

✍ A Suwa; T Yamamoto; A Sawada; K Minoura; N Hosogai; A Tahara; T Kurama; T Shimok 📂 Article 📅 2009 🏛 Nature Publishing Group 🌐 English ⚖ 411 KB

415 POSTER Discovery and characterizatio

415 POSTER Discovery and characterization of novel small molecule inhibitors of polo-like kinase-1, using a computational development process

✍ C. Olsen; C. Grand; H. Vankayalapati; X. Zhang; J. Redman; J. Sunseri; M. Lloyd; 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 57 KB

Novel orally available brain penetrant s

Novel orally available brain penetrant small molecule inhibitors of ganglioside biosynthesis for the treatment of Sandhoff and Tay–Sachs diseases

✍ Bai, Xiaomei; Sun, Hong; Tang, Lan; Duron, Sergio; Bhagwat, Shripad; Crawford, B 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 309 KB

Preclinical characterization of RO460252

Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

✍ Borroni, Edilio; Wyler, Rene; Messer, Juergen; Nave, Stephane; Cesura, Andrea 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 51 KB

Pre-clinical characterization of CX-4945

Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

✍ Fabrice Pierre; Peter C. Chua; Sean E. O’Brien; Adam Siddiqui-Jain; Pauline Bour 📂 Article 📅 2011 🏛 Springer 🌐 English ⚖ 446 KB