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The determination of the uptake of arabinosyl-6-mercaptopurine by L1210 cells

✍ Scribed by David Li-Shan Chao; A.P. Kimball


Book ID
115721901
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
313 KB
Volume
266
Category
Article
ISSN
0005-2736

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Inhibition of methionine uptake by metho
✍ Kevin J. Scanlon; Arlene R. Cashmore; Mohammed Kashani-Sabet; Michele Pallai; Ro πŸ“‚ Article πŸ“… 1987 πŸ› Springer 🌐 English βš– 355 KB

Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX