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The design, synthesis of amide KARI inhibitors and their biological activities

✍ Scribed by Baolei Wang; Yi Ma; Yonghong Li; Suhua Wang; Zhengming Li


Book ID
107373685
Publisher
Higher Education Press and Springer
Year
2009
Tongue
English
Weight
102 KB
Volume
4
Category
Article
ISSN
1673-3495

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Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical