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Molecular design and biological activities of protein-tyrosine phosphatase inhibitors

✍ Scribed by Kazuo Umezawa; Mariko Kawakami; Takumi Watanabe


Book ID
114129360
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
802 KB
Volume
99
Category
Article
ISSN
0163-7258

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Several alkyl-and O-methylated-3,4 -dephostatin were synthesized and evaluated for their inhibitory activity toward protein tyrosine phosphatase. Alkyl chains with a length up to that of the pentyl group gave tolerable inhibition, whereas methylation of hydroxyl groups resulted in a decrease in the