๐”– Bobbio Scriptorium
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The design of peptide hormone analogs

โœ Scribed by John M. Stewart


Book ID
119110877
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
573 KB
Volume
3
Category
Article
ISSN
0165-6147

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Conformational and dynamic consideration
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## Synopsis Efforts to understand the chemical-physical basis for peptide hormone and neurotransmitter action requires integration of conformational parameters and biological properties. Since most peptide hormones are conformationally flexible, the question arises as to which of the manifold of c

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## Abstract A series of peptideโ€“peptoid hybrids, containing __N__โ€substituted glycines, were synthesized based on the Hโ€Aibโ€Valโ€Aibโ€Gluโ€Ileโ€Glnโ€Leuโ€Nleโ€Hisโ€Glnโ€Harโ€NH~2~ (Har = Homoarginine) as the parent parathyroid hormone (1โ€“11) analog. The compounds were pharmacologically characterized in their