Peptide–peptoid hybrids based on (1–11)-parathyroid hormone analogs

✍ Scribed by A. Caporale; E. Schievano; E. Peggion

• Book ID: 105359894
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 215 KB
• Volume: 16
• Category: Article
• ISSN: 1075-2617
• DOI: 10.1002/psc.1265

✦ Synopsis

Abstract

A series of peptide–peptoid hybrids, containing N‐substituted glycines, were synthesized based on the H‐Aib‐Val‐Aib‐Glu‐Ile‐Gln‐Leu‐Nle‐His‐Gln‐Har‐NH~2~ (Har = Homoarginine) as the parent parathyroid hormone (1–11) analog. The compounds were pharmacologically characterized in their agonistic activity at the parathyroid hormone 1 receptor. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.