The design and synthesis of a conformationally constrained trisaccharide for probing carbohydrate-protein interactions
β Scribed by N. Navarre; A.H. van Oijen; G.J. Boons
- Book ID
- 104256594
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 267 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The synthesis of the macrocyclic trisaccharide H which is conformationally restricted around its glycosidic linkages and which can adopt a conformation required for binding with the lectin LOLl
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Conformationally constrained amino acid and dipeptide units can serve in mimics of specific secondary structures for studying relationships between peptide conformation and biological activity. A variety of mimics are required to study systematically the structure-activity relationships in biologica
The design as well as the synthesis, resolution, and biological evaluation of the neutral endopeptidase 24.11 inhibitors, (1S,2R,5S)-(-)-[(2-mercapto-5-phenyl-cyclopentanecarbonyl)amino]-acetic acid and (1R,2S,5R)-(+)- [(2-mercapto-5-phenyl-cyclopentanecarbonyl)-amino]-acetic acid are described.