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The Design and Evaluation of Heparin-Binding Foldamers

โœ Scribed by Sungwook Choi; Dylan J. Clements; Vojislava Pophristic; Ivaylo Ivanov; Satyavani Vemparala; Joel S. Bennett; Michael L. Klein; Jeffrey D. Winkler; William F. DeGrado

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
182 KB
Volume
117
Category
Article
ISSN
0044-8249

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Heparin-induced thrombocytopenia (HIT) is mediated by antibody against complexes of platelet factor-4 (PF4) and heparin. Although it has been assumed that these complexes bind to platelets and provide a target for the antibody, this has never been demonstrated. Furthermore, there is evidence suggest