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The der(II) chromosome contains the critical breakpoint junction in the 4;11, 9;11, and 11;19 translocations in acute leukemia

✍ Scribed by Dr. Janet D. Rowley

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
227 KB
Volume
5
Category
Article
ISSN
1045-2257

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✦ Synopsis

Translocations involving I I q23 are recurring abnormalities in human acute leukemia cells of either lymphoid or rnyeloid lineage. Analysis of I 3 variant translocations associated with four of these [t(4; I I), t(6; I I), t(9; I I ) and t( I I ; I9)] reveals that the der( I I) chromosome is conserved in all of them and therefore contains the critical genetic rearrangement. The M l L gene (myeloidl lymphoid leukemia) is involved in each of these translocations. It is transcribed from centromere to telomere. The present analysis indicates that the 5' region of M l L on the der( I I) is juxtaposed to the coding sequences of genes on each of the other translocation partners. Genes Chrorn Cancer 5264-266 (I 992)

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