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The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth

✍ Scribed by Cañibano, Carmen; Rodriguez, Noela L; Saez, Carmen; Tovar, Sulay; Garcia-Lavandeira, Montse; Borrello, Maria Grazia; Vidal, Anxo; Costantini, Frank; Japon, Miguel; Dieguez, Carlos


Book ID
110032010
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
568 KB
Volume
26
Category
Article
ISSN
0261-4189

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## BACKGROUND. Apoptosis is induced by various anticancer agents or radiation through the tumor suppressor gene p53-dependent pathway and is also induced by other factors, including transforming growth factor-PI (TGF-0,). In this study, the authors investigated whether TGF-0, would induce apoptosi