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A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes

✍ Scribed by Yosuke Hattori; Toshihisa Kojima; Daizo Kato; Hiroyuki Matsubara; Masaharu Takigawa; Naoki Ishiguro

Book ID: 116303257
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 746 KB
Volume: 421
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2012.03.111

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## Abstract Ascochlorin, a non‐toxic prenylphenol compound derived from the fungus __Ascochyta viciae__, has been shown recently to have anti‐cancer effects on various human cancer cells. However, the precise molecular mechanism of this anti‐cancer activity remains to be elucidated. Here, we invest