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The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on neuroblastoma cell lines

✍ Scribed by Jörgen Bierau; Albert H. van Gennip; Jozien Helleman; André B.P. van Kuilenburg

Book ID
113992781
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
144 KB
Volume
62
Category
Article
ISSN
0006-2952

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✍ Arnauld C. Verschuur; Albert H. Van Gennip; René Leen; P.A. Voûte; Josanne Brink 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 170 KB

## Abstract The cytotoxic effect of 1‐β‐D‐arabinofuranosyl cytosine (araC) depends on the intracellular phosphorylation into its active compound araCTP, on the degree of degradation of araCTP and on the incorporation of araCTP into DNA. Deoxycytidine triphosphate (dCTP) inhibits the phosphorylation